Nosso laboratório estará recebendo o Dr. Robert Fuchs (CNRS-França) para uma visita de colaboração científica, durante os dias de 21 a 30 de abril. Dentre as atividades propostas está a oferta de um curso teórico sobre mecanismos de reparo de DNA e replicação. A programação segue abaixo.
O Dr. Fuchs é uma das referências mundiais na área de mutagênese e reparo de DNA, tendo feito contribuições científicas
de grande relevância como a descoberta e caracterização da DNA polimerase IV (gene dinB). Abaixo segue um breve resumo do currículo do Dr. Fuchs.
Segue a programação das aulas que serão ministradas pelos Dr. Robert Fuchs e Dra. Rita Napolitano (CNRS-França), de 24 a 27 de abril, as 9 h na sala SS1 do DBG:
24/04 – Rita Napolitano – Bacteriófagos e Transdução
25/04 – Robert Fuchs – How DNA lesions are converted into mutations ?
26/04 – Robert Fuchs – Control of spontaneous and induced mutagenesis by dNTP pool size.
27/04 – Robert Fuchs – O6-alkylguanine metabolism: eATL modulates the action of NER and MMR.
Dr Robert Fuchs is the Head of the newly created (2006) CNRS Unit “Genome Instability and Carcinogenesis” located in Marseille. This Unit (12 permanent staff scientists; 4 technicians, 10 postdocs and 6 PhD students) is divided into 5 teams that are all involved in unravelling the mechanisms involved in genome stability. During his whole career Dr Fuchs has worked on the effect of lesions on DNA replication. He was first to establish a forward mutation spectrum induced by a chemical carcinogen belonging to the class of aromatic amides and to correlate frameshift mutagenesis to specific
hot spot sequences. This was followed by structural analysis of single-adducted DNA and mutational analysis at one-nucleotide resolution within the NarI hotspot. More recently, he has been one of the pioneers behind the exciting work on the novel class of DNA polymerases responsible for translesion DNA synthesis (Y-polymerases), which involve discoveries that have challenged much of the established concepts about mutagenesis.
Among the main contributions, his lab discovered the 4th DNA polymerase in E. coli, namely Pol IV, the dinB gene product and demonstrated the functional uncoupling between the leading and lagging strand synthesis during lesion bypass in vivo. His scientific production includes more than 160 published papers.